Dr Liston asks Prof. Best to describe the moment when he and Dr Banting first realised they had been successful in treating a diabetic dog. He describes this period of research, in July 1921, and Dr Lawrence asks further questions. Dr Lawrence then describes the period of his life from when he was diagnosed with diabetes at the age of 27, to when his doctor contacted him to tell him of insulin. He had been very ill, but says that from the first few days of treatment with insulin he knew his condition would vastly improve. He also describes how in the early C.20th, people with diabetes would die within a few years of diagnosis. Prof. Best then describes how he and Dr Banting furthered their research.