The rediscovery of Symbiopsychotaxiplasm: Take One in 1991, and the widespread recognition it received, prompted Greaves to consider returning to the original project, which had been developed on the assumption that funding would be available for five ‘Takes’. When it became clear that Steven Soderbergh and Steve Buscemi would support a new Symbio experiment, Greaves brought one of the original couples, Audrey Henningham and Shannon Baker (seen in Take One only briefly), back together to play their original characters, and be themselves, now 37 years older. Other veterans of Take One also take part.