Holy Smokes follows best friends and Catholic school survivors, prudish Emma and “corrupted stoner” Lauren. Indebted to her friend, Lauren drives Emma across the state to meet her online boyfriend, Johnny, a “pastor’s son” she met on HolyHookup.net. Upon arriving to Johnny’s house, the girls discover that not only is he not a pastor’s son, but he isn’t the age he claimed to be either. And when they meet Mommy, Johnny’s step-mom who cares way too much about his sex life, things start to get… weird.