“Breakthrough: Portraits of Women in Science” is a short film anthology from Science Friday and Howard Hughes Medical Institute (HHMI) that follows women working at the forefront of their fields. Each episode blends deeply personal stories with innovative scientific research of women across STEM fields and takes viewers to places like the Arctic and to India’s space agency. By showing that challenges such as deeply-rooted cultural or institutional norms, grueling working conditions, or personal tragedy and sacrifice are not insurmountable obstacles to becoming a scientist or engineer, “Breakthrough” hopes to inspire a future generation of women to lead careers in STEM fields.